Services / MLPA® technique
MLPA (Multiplex Ligation-dependent Probe Amplification) is a multiplex PCR method detecting copy numbers of up to 60 different genomic DNA sequences, which is able to distinguish sequences differing in only one nucleotide. MLPA reactions require only 50 ng of human chromosomal DNA. It can be used for a wide variety of disorders including: the detection of exon deletions/duplications in e.g. the human BRCA1, MSH2 and MLH1 genes, detection of trisomies such as Down syndrome, characterisation of chromosomal aberrations in cell lines and tumour samples, SNP and mutation detection, DNA methylation analysis. The MLPA technique is easy to use, as it only requires a thermocycler and capillary electrophoresis equipment.
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OPA1
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CHEK2 Test
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BRCA1 Test
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BRCA2 Test